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ENHANCEMENT OF INTRINSIC ANTITUMOR ACTIVITY IN SPORE‐ENDOTOXIN MIXTURES OF Bacillus thuringiensis BY EXPOSURE TO ULTRAVIOLET RADIATION
Author(s) -
Zamola B.,
KarminskiZamola G.,
Fuks Zê.,
Kubovicê M.,
Wrischer M.
Publication year - 1985
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1985.tb03498.x
Subject(s) - bacillus thuringiensis , lewis lung carcinoma , spore , potency , chemistry , ultraviolet , inoculation , ultraviolet radiation , microbiology and biotechnology , biochemistry , in vitro , biology , bacteria , immunology , radiochemistry , cancer , materials science , genetics , optoelectronics , metastasis
— Irradiation of spore‐endotoxin mixtures from Bacillus thuringiensis cultures at 254 nm (60 μW cm ‐2 ) enhances their intrinsic antitumor potency as well as that of either component. The extent of enhancement depends on the length of exposure (optimum: 35 min) and may thus be due to photochemical changes of the endotoxin protein or/and to photoproduction of additional compounds with antitumor activity. Antitumor effects, expressed as survival rates of C57BL/6 mice inoculated with Lewis' mouse lung carcinoma and subjected to treatments 24 h later, depended on the number of doses of preparations administered (mixture, separated components).