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INDUCTION OF CHROMOSOME ABERRATIONS IN ICR 2A FROG CELLS EXPOSED TO265–313 nm MONOCHROMATIC ULTRAVIOLET WAVELENGTHS and PHOTOREACTIVATING LIGHT
Author(s) -
Rosenstein Barry S.,
Rosenstein Rebecca B.
Publication year - 1985
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1985.tb03448.x
Subject(s) - monochromatic color , pyrimidine dimer , chromatid , wavelength , chromosome , ultraviolet , biology , biophysics , irradiation , optics , microbiology and biotechnology , genetics , physics , dna , dna repair , gene , nuclear physics
Abstract— Exposure of ICR 2A cells to either 265, 289, 302 or 313 nm monochromatic UV wavelengths caused the induction of chromosome aberrations with chromatid gaps and breaks being the most common type of aberration detected. Treatment of U V‐irradiated cells with photoreactivating light (PRL) resulted in a lower yield of aberrations demonstrating that pyrimidine dimers are involved in the formation of chromosome aberrations induced by the UV wavelengths tested. However, the decrease in the level of aberrations resulting from PRL treatment of 313 nm‐irradiated cells was significantly less than for the other wavelengths indicating that non‐dimer photoproducts may have played an important additional role in the induction of chromosome aberrations by this UV wavelength.