Premium
GIANT CELL FORMATION IN BLADDER TUMOR CELLS FOLLOWING HEMATOPORPHYRIN DERIVATIVE‐SENSITIZED PHOTOIRRADIATION
Author(s) -
BELLNIER DAVID A.,
LIN CHIWEI
Publication year - 1984
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1984.tb08200.x
Subject(s) - hematoporphyrin , giant cell , chemistry , cell , derivative (finance) , microbiology and biotechnology , biophysics , photodynamic therapy , pathology , biology , biochemistry , medicine , organic chemistry , financial economics , economics
— Giant cell induction was studied in cultured bladder tumor cells (MGH‐Ul; commonly referred to as “EJ”) following hematoporphyrin derivative (HpD)‐sensitized photoirradiation. Eight days after treatment, control colonies (no treatment, HpD alone, light alone) were generally uniform in size and density and contained few giant cells. Colony heterogeneity and giant cell frequency increased with light dose in the presence of HpD. The morphology and frequency of giant cell formation, with respect to survival levels, were comparable to those observed in 280 kVp X‐irradiation of the same cells.