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ANOXIC PHOTODAMAGE IN THE PRESENCE OF PORPHYRINS: EVIDENCE FOR THE LACK OF EFFECTS ON MITOCHONDRIAL MEMBRANES
Author(s) -
Salet C.,
Moreno G.,
VeverBizet C.,
Brault D.
Publication year - 1984
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1984.tb04567.x
Subject(s) - hematoporphyrin , anoxic waters , membrane , oxygen , mitochondrion , liposome , irradiation , biophysics , chemistry , membrane potential , respiration , photosensitizer , photochemistry , biochemistry , biology , photodynamic therapy , environmental chemistry , anatomy , physics , organic chemistry , nuclear physics
When isolated mitochondria are irradiated in the presence of 50 μg/ml hematoporphyrin or hematoporphyrin derivative in the respiratory medium, the irradiation is at least twenty‐fold less effective in impairing the Ca 2+ pump in the absence of oxygen than in its presence. This result suggests that photosensitization by non oxygen‐depending pathways has few or no effects on cell membranes, a result somewhat at variance with those observed with liposomes.