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A LASER FLASH PHOTOLYSIS AND PULSE RADIOLYSIS STUDY OF AMILORIDE IN AQUEOUS AND ALCOHOLIC SOLUTION
Author(s) -
Hamoudi H. I.,
Heelis P. F.,
Jones R. A.,
Navaratnam S.,
Parsons B. J.,
Phillips G. O.,
Vandenburg M. J.,
Currie W. J. C.
Publication year - 1984
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1984.tb04550.x
Subject(s) - radiolysis , chemistry , photochemistry , amiloride , flash photolysis , aqueous solution , photodissociation , radical ion , solvated electron , methanol , radical , ion , kinetics , sodium , reaction rate constant , organic chemistry , physics , quantum mechanics
Laser flash photolysis and pulse radiolysis have been carried out on the diuretic drug amiloride. The primary photochemical processes in aqueous solution were found to be photoionisation and triplet formation. Photoionisation was found to occur by a biphotonic process for 265 nm excitation but by a monophotonic process for excitation at 353 nm. The spectral properties of the resulting cation radical of amiloride were determined by pulse radiolysis using one electron oxidation by the radical anion Br 2 · ¯ Photoexcitation of amiloride in isopropanol did not result in photoionisation but instead a semireduced radical of amiloride was observed. The spectral properties of the semireduced radical of amiloride were determined using one electron reduction by the CO 2 · ¯ radical.