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COMPARISON OF THE PHOTOTOXICITY OF α‐TERTHIENYL WITH THAT OF A SELENIUM AND OF AN OXYGEN ANALOGUE
Author(s) -
Garcia F. J.,
Yamamoto E.,
Abramowski Z.,
Downum K.,
Towers G. H. N.
Publication year - 1984
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1984.tb03886.x
Subject(s) - phototoxicity , singlet oxygen , selenium , chemistry , furan , escherichia coli , oxygen , yeast , photochemistry , biochemistry , organic chemistry , in vitro , gene
Abstract— Two analogues of α‐terthienyl, namely 2, 5di(2'‐thienyl) selenophene and 2, 5di(2'‐thienyl) furan have been prepared and their phototoxicities toward several microorganisms have been compared. Dose response studies with Escherichia coli indicate that α‐terthienyl is more active than these analogues. α‐Terthienyl was shown to be the most effective of the three compounds in the photoinactivation of yeast alcohol dehydrogenase. Diagnostic tests showed the participation of singlet oxygen in the photosensitization to different extents by these three thiophenes.