Premium
PHOTODYNAMIC INACTIVATION OF CHINESE HAMSTER CELLS
Author(s) -
Ganguly Tapan,
Bhattacharjee Sukhendu B.
Publication year - 1983
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1983.tb08367.x
Subject(s) - acriflavine , chinese hamster , sodium azide , singlet oxygen , hamster , chemistry , dna , irradiation , biophysics , photochemistry , oxygen , microbiology and biotechnology , biochemistry , biology , physics , organic chemistry , nuclear physics
— Visible light exposures have been shown to kill acriflavine bound Chinese hamster cells. Such killing was enhanced when (a) dye was present in the medium during irradiation and (b) the pH of the medium was 8.5, instead of the normal 7.5 during the exposure. The induced killing could be suppressed by the presence of sodium azide during exposure. The results were taken to indicate that both DNA and non‐DNA sites were involved in the cellular inactivation by visible light and that singlet oxygen was involved in the process.