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SV40 INDUCTION FROM A MAMMALIAN CELL LINE BY ULTRAVIOLET RADIATION and THE PHOTOSENSITIZERS 8‐METHOXYPSORALEN and ANGELICIN
Author(s) -
Moore Sharon P.,
Blount Howard,
Coohill Thomas P.
Publication year - 1983
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1983.tb04537.x
Subject(s) - methoxsalen , chemistry , ultraviolet radiation , ultraviolet , photosensitizer , weanling , cell culture , photochemistry , dermatology , biology , medicine , materials science , optoelectronics , genetics , radiochemistry , psoriasis , endocrinology
SV40‐transformed weanling Syrian hamster kidney cells were exposed to long wavelength ultraviolet radiation in the presence of 8‐methoxypsoralen or angelicin. The number of viruses induced as a result of this treatment was quantitated on CV‐1P cells. The results indicate that angelicin, which is generally believed to form only monoadducts, is a potent viral inducing agent even when compared with 8‐methoxypsoralen (8‐MOP), which forms both monoadducts and crosslinks. At low radiation exposures 8‐MOP is more effective than angelicin; as the radiation exposure is increased angelicin is capable of inducing the same peak level of virus expression as was 8‐MOP. It appears that the induction of SV40 is a phenomenon possibly related to the repair of monoadducts.