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THE LIPID SOLUBILITY OF PORPHYRINS MODULATES THEIR PHOTOTOXICITY IN MEMBRANE MODELS
Author(s) -
Emiliani Carla,
Delmelle Michel
Publication year - 1983
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1983.tb04505.x
Subject(s) - hematoporphyrin , protoporphyrin , phototoxicity , chemistry , liposome , lecithin , membrane , context (archaeology) , egg lecithin , lipid bilayer , bilayer , porphyrin , solubilization , solubility , hemin , protoporphyrin ix , biophysics , photochemistry , chromatography , biochemistry , heme , organic chemistry , in vitro , photodynamic therapy , enzyme , paleontology , biology
The photosensitizing activities of hematoporphyrin, Cu‐hematoporphyrin, protoporphyrin. Zn‐protoporphyrin, deuteroporphyrin and uroporphyrin are studied. The relative yields of 1 O 2 are measured in buffer (pH 8.0) and compared to the yields of Type II photodamages induced on cholesterol embedded in egg lecithin liposomes. Results show that the solubilization of the sensitizer in the lipid bilayer is a prerequisite for its photosensitizing activity at the membrane level. In this context, the partition coefficient represents an important parameter.