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FREE RADICALS FROM PHOTOREDUCTION OF HEMATOPORPHYRIN IN AQUEOUS SOLUTION
Author(s) -
Felix C. C.,
Reszka K.,
Sealy R. C.
Publication year - 1983
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1983.tb04449.x
Subject(s) - hematoporphyrin , chemistry , photochemistry , radical , porphyrin , electron paramagnetic resonance , pyrogallol , aqueous solution , reducing agent , spin trapping , glutathione , hydrogen peroxide , organic chemistry , nuclear magnetic resonance , physics , photodynamic therapy , enzyme
—The anaerobic photoreduction of hematoporphyrin by organic reducing agents in fluid aqueous solutions has been studied by electron spin resonance spectroscopy. Efficient photoreduction occurs with many hydrogen‐atom or electron donors, including catechols, pyrogallol. hydroquinone. ascorbate, p ‐phenylenediamine, cysteine and glutathione. A combination of direct and spin‐trapping measurements (using 2‐methyl‐2‐nitrosopropane) has been used to confirm production of radicals from both the porphyrin and the reducing agent in each system.