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PHOTOPHARMACOLOGY OF THE TRANQUILIZER CHLORDIAZEPOXIDE IN RELATION TO ITS PHOTOTOXICITY
Author(s) -
Bakri† A.,
Henegouwen G. M. J. Beijersbergen van,
Chanal J. L.
Publication year - 1983
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1983.tb03859.x
Subject(s) - chlordiazepoxide , chemistry , pharmacology , phototoxicity , irradiation , biochemistry , biology , diazepam , in vitro , physics , nuclear physics
— This study demonstrates that photobiological effects by exogenous molecules are not per se restricted to the skin. As an example the photopharmacology of chlordiazepoxide (e.g. Librium R ) was studied. Rats being exposed to UV‐A after administration of 14 C 2 labeled chlordiazepoxide (CDZ) showed a marked change in the pattern of urinary metabolites; the quantity of metabolites without N 4 ‐oxide function increased, whereas that of compounds with N 4 ‐oxide function decreased. Covalent binding to organ tissue of especially liver and skin of the irradiated rats was found. This would mean that in the irradiated rats oxaziridines which may also react with tissue of the inner organs are formed from CDZ and its N 4 ‐oxymetabolites. Further, the combination of light and CDZ leads to a 30% decrease in weight of the liver, indicating liver damage. This is also supported by the percentage of conjugated urinary metabolites being 1.5–2.5 times lower than in the non‐irradiated CDZ‐treated rats, possibly caused by a decrease of enzymatic activity. The administration of CDZ‐oxaziridine to non‐irradiated rats provoked the same effects, such as a decrease of the weight of the liver comparable to that of irradiated CDZ‐treated rats. On the other hand the combination of light and treatment with N 4 ‐desoxy CDZ did not have any effect, as expected.