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PHOTOGENERATION OF SUPEROXIDE ION and HYDROGEN PEROXIDE FROM TRYPTOPHAN and ITS PHOTOOXIDATION PRODUCTS: THE ROLE OF 3a‐HYDROPEROXYPYRROLIDINOINDOLE*
Author(s) -
Inoue Kenzo,
Matsuur Teruo,
Saito Isao
Publication year - 1982
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1982.tb03822.x
Subject(s) - superoxide , hydrogen peroxide , photochemistry , chemistry , tryptophan , singlet oxygen , oxygen , irradiation , ion , peroxide , reactive oxygen species , organic chemistry , biochemistry , amino acid , enzyme , physics , nuclear physics
— Mechanism of the photogeneration of hydrogen peroxide and superoxide ion from tryptophan (Trp) and its photooxidation products was investigated. Near‐ultraviolet irradiation of 3a‐hydro‐peroxypyrrolidinoindole, an intermediate in the photooxidation of Trp, has been shown to generate hydrogen peroxide efficiently under aerobic conditions. Irradiation of N‐formylkynurenine in the presence of 3α‐hydroxypyrrolidinoindole also produced hydrogen peroxide. The formation of superoxide ion in both reactions has been confirmed, whereas the reaction of Trp with chemically generated singlet oxygen did not produce any detectable amount of superoxide ion.