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PHOTOMIMETIC EFFECT OF SEROTONIN ON YEAST CELLS IRRADIATED BY FAR‐UV RADIATION
Author(s) -
Marina G. Y. Fraikin,
Strakhovskaya G.,
Rubin Leonid B.
Publication year - 1982
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1982.tb02650.x
Subject(s) - serotonin , yeast , irradiation , long term potentiation , saccharomyces cerevisiae , biophysics , lethality , radiation , biology , chemistry , biochemistry , toxicology , optics , receptor , physics , nuclear physics
— The effect of serotonin on the survival of far‐UV irradiated cells of the yeast Candida guillier‐mondii was studied. Serotonin was found to have a photomimetic property. Preincubation of cells with serotonin results in protection against far‐UV inactivation, whereas the post‐radiation treatment with serotonin causes a potentiation of far‐UV lethality. Both effects are similar to those produced by near‐UV (334 nm) radiation. The observations provide support to the idea advanced by us previously that photosynthesized serotonin is the underlying cause of the two effects of near‐UV radiation, photo‐protection and potentiation of far‐UV lethality. Experiments with an excision‐deficient strain of the yeast Saccharomyces cerevisiae suggest that the effect of serotonin is by its binding to DNA.