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REACTIVATION OF UV‐ AND γ‐IRRADIATED HERPES VIRUS IN UV‐ AND X‐IRRADIATEDCV–1 CELLS
Author(s) -
Takimoto Koichi,
Niwa Ohtsura,
Sugahara Tsutomu
Publication year - 1982
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1982.tb02599.x
Subject(s) - virus , irradiation , herpes virus , virology , biology , chemistry , microbiology and biotechnology , physics , nuclear physics
— Enhanced reactivation of UV‐ and y‐irradiated herpes virus was investigated by the plaque assay onCV–1 monkey kidney monolayer cells irradiated with UV light or X‐rays. Both UV‐ and X‐irradiatedCV–1 cells showed enhancement of survival of UV‐irradiated virus, while little or no enhancement was detected for y‐irradiated virus assayed on UV‐ or X‐irradiated cells. The enhanced reactivation of UV‐irradiated virus was greater when virus infection was delayed 24 or 48 h, than for infection immediately following the irradiation of cells. It is demonstrable that the UV‐ or X‐irradiatedCV–1 cells are able to enhance the repair of UV damaged herpes virus DNA, but not of y‐ray damaged ones.