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SYSTEMIC INFLUENCE OF PRE‐IRRADIATION OF A LIMITED SKIN AREA ON UV‐TUMORIGENESIS
Author(s) -
Gruul F. R. de,
Leun J. C.
Publication year - 1982
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1982.tb02577.x
Subject(s) - hairless , irradiation , carcinogenesis , shielded cable , skin tumor , medicine , cancer research , chemistry , cancer , biochemistry , physics , nuclear physics , electrical engineering , engineering
— It has been established that chronic UV irradiation of mice produces a systemic effect. The animals become incapable of rejecting an implanted UV‐induced tumor. A possible consequence of the induction of this systemic effect could be an enhancement of the de novo formation of tumors by chronic UV irradiation. We have therefore carried out an investigation to determine whether such an effect is demonstrable in an animal model. Hairless mice (Skh hr 1) were pre‐irradiated for a few months with UV radiation while certain skin areas of the animals were shielded from the radiation. Subsequently, the initially shielded skin areas were chronically exposed to UV radiation, which resulted in the development of tumors in these skin areas. It was found that the formation of tumors in the initially shielded skin areas was enhanced by the pre‐irradiation of the other skin areas. Thus, a systemic effect appeared to have influenced the development of tumors in the initially shielded skin areas.