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SINGLET OXYGEN FORMATION BY SENSITIZATION OF FUROCOUMARINS COMPLEXED WITH, OR BOUND COVALENTLY TO DNA
Author(s) -
Mol N. J.,
Henegouwen G. M. J. Beijersbergen,
Beele B.
Publication year - 1981
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1981.tb09060.x
Subject(s) - furocoumarins , singlet oxygen , sensitization , photochemistry , chemistry , covalent bond , dna , phototoxicity , singlet state , oxygen , biophysics , biochemistry , excited state , biology , organic chemistry , physics , nuclear physics , immunology , in vitro
— The formation of singlet molecular oxygen ( 1 O 2 ) by sensitization of the furocoumarins 5‐methoxypsoralen (5‐MOP), 8‐methoxypsoralen (8‐MOP) and psoralen complexed with DNA was investigated. From the results it is concluded that 5‐MOP complexed with native DNA is able to generate 1 O 2 , even in a larger extent than 5‐MOP free in solution. Also, with 8‐MOP and especially with psoralen, 1 O 2 formation by the complexed compound could be observed. The 1 O 2 formation sensitized by covalently bound furocoumarin was demonstrated with psoralen as a model compound. 4′,5′‐Dihydropsoralen, a model compound for the UVA light absorbing 4′,5’monoadducts of furocoumarins to DNA, is also able to generate 1 O 2 .