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4,4′‐DIMETHYLANGELICIN, A MONOFUNCTIONAL FUROCOUMARIN SHOWING HIGH PHOTOSENSITIZING ACTIVITY
Author(s) -
Baccichetti F.,
Bordin F.,
Carlassare F.,
Peron M.,
Guiotto A.,
Rodighiero P.,
Dall'Acqua F.,
Tamaro M.
Publication year - 1981
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1981.tb09056.x
Subject(s) - furocoumarin , chemistry , furocoumarins , biochemistry , photochemistry , dna
— 4,4′‐Dimethylangelicin, a monofunctional furocoumarin, showed a high photosensitizing activity on various biological substrates. The lethal effect on Escherichia coli B 48 , a wild type strain, and the extent of DNA synthesis inhibition in Ehrlich ascites tumor cells, were not only much more pronounced than that observed with the previously studied monofunctional 4,5′‐dimethylangelicin, but even higher than with bifunctional psoralen, 4,4′‐Dimethylangelicin, contrary to the other methylangelicin, proved to be phototoxic on guinea pig skin and showed an evident mutagenic effect in E. coli WP 2 , but to a much lower extent than psoralen.