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PHOTOINDUCED REACTION OF DIMETHYLNITROSAMINE WITH DNA AND POLYNUCLEOTIDES
Author(s) -
Arfellini G.,
Prodi G.,
Rocchi P.,
Grilli S.
Publication year - 1981
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1981.tb09055.x
Subject(s) - chemistry , polynucleotide , nucleic acid , dna , methylhydrazine , depurination , biochemistry , in vivo , nitrosamine , trimethylamine , photochemistry , organic chemistry , carcinogen , biology , genetics , propellant
— The interaction between products from dimethylnitrosamine photolytic breakdown and DNA is time‐dependent and the reaction with polyguanylic acid is 36 times higher than that occurring with other polyribonucleotides; such interactions occur only if nucleic acids are present during dimethylnitrosamine photolytic breakdown. Among interaction compounds, neither O 6 ‐methyl‐ nor 7‐methylguanine are observable; on the contrary, N‐methylhydrazine and trimethylamine are always found in acid and alkaline hydrolysates of DNA and polynucleotides. These findings are very similar to the results previously found in biological in vivo and in vitro systems and suggest a possible usefulness of this physicochemical system as an analogical model of chemical carcinogenesis.