Premium
PHOTOREPAIR OF PYRIMIDINE DIMERS IN HUMAN SKIN IN VIVO
Author(s) -
D'Ambrosio Steven M.,
Whetstone James W.,
Slazinski Leonard,
Lowney Edmund
Publication year - 1981
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1981.tb09025.x
Subject(s) - pyrimidine dimer , human skin , in vivo , visible spectrum , pyrimidine , irradiation , photochemistry , chemistry , endonuclease , biophysics , radiation , dna , materials science , dna damage , stereochemistry , biochemistry , optics , optoelectronics , biology , physics , genetics , nuclear physics , microbiology and biotechnology
— The exposure of human skin in vivo to UV radiation emitted from a sunlamp induces the formation of pyrimidine dimers. The number of dimers, as detected by UV‐endonuclease, decreases following exposure of the UV–irradiated skin to visible wavelengths of light. These results suggest that humans possess a mechanism by which pyrimidine dimers are photorepaired upon illumination of human skin in vivo with visible light.