Premium
MUTAGENICITY OF MONOADDUCTS AND CROSS‐LINKS INDUCED IN ASPERGILLUS NIDULANS BY 8‐METHOXYPSORALEN PLUS 365 NM RADIATION
Author(s) -
Scott Barry R.,
Maley Mary Ann
Publication year - 1981
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1981.tb08962.x
Subject(s) - aspergillus nidulans , furocoumarin , kinetics , aspergillus , chemistry , radiation , dna , biology , biochemistry , microbiology and biotechnology , mutant , physics , gene , quantum mechanics
— 8‐Methoxypsoralen plus 365 nm radiation induces mutation at the methionine supressor loci of Aspergillus inhibitor‐deficient conidia at low doses of near‐UV radiation with one‐hit kinetics and at higher near‐UV radiation doses with two‐hit kinetics. These results and others suggest that both monoadducts and cross‐links, formed by 8‐methoxypsoralen and DNA upon exposure to UV radiation, are capable of inducing mutation. Evidence is also presented that induced furocoumarin cross‐links are responsible for the inactivation of the Aspergillus conidium.