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DYE BINDING AND PHOTODYNAMIC ACTION
Author(s) -
Amagasa Jumpei
Publication year - 1981
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1981.tb05519.x
Subject(s) - singlet oxygen , chemistry , biomolecule , photodynamic therapy , flavin group , photochemistry , combinatorial chemistry , porphyrin , oxygen , biochemistry , organic chemistry , enzyme
A variety of natural and synthetic compounds can act as effective photosensitizers in biological systems, including psoralens, flavins, porphyrins, acridines, phenothiazines, xanthenes, quinones, polyenes, haloaromatics and inorganic ions. These, in the presence of light and oxygen, inactivate and modify the integrity of important biomolecules and cellular structures, leading to cell death, mutation and other special function losses [70,118,119]. Many photosensitizers can act as mediators of photodynamic and non‐photodynamic reactions, depending on the experimental conditions. Although a great variety of photosensitized reactions may occur with different sensitizers and substrates, they can be classified into two types of reaction mechanisms, that is, Type I (radical) and Type II (singlet oxygen; 1 O 2 ) mechanisms. Type I and Type II reactions for important biomolecules have recently been reviewed [27, 119].