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RELATION BETWEEN SOME PHOTOBIOLOGICAL PROPERTIES OF FUROCOUMARINS AND THEIR EXTENT OF SINGLET OXYGEN PRODUCTION
Author(s) -
De Mol N. J.,
Beijersbergen van Henegouwen G. M. J.
Publication year - 1981
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1981.tb05497.x
Subject(s) - furocoumarins , psoralen , singlet oxygen , furocoumarin , phototoxicity , chemistry , photochemistry , oxygen , organic chemistry , biochemistry , dna , in vitro
— The production of singlet oxygen ( 1 O 2 ) by a series of furocoumarins with different skin sensitizing abilities has been investigated with methods already proven to be suitable to establish the ability of 8‐methoxypsoralen (8‐MOP) to generate 1 O 2 . The following compounds: 5‐methoxypsoralen (5‐MOP), psoralen, 4,5′,8‐trimethylpsoralen (TMP) and 5,8–dimethoxypsoralen (5,8–DMOP), are able to generate 1 O 2 when irradiated with long–wave ultraviolet light. With the photobiologically inactive angelicin no 1 O 2 production has been found. The relative extent of 1 O 2 formation has been determined for the various furocoumarins and has been compared with literature data for the skin photosensitizing effect. The observed relation between experimental data on the one side and the literature data on the other side is discussed.