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PHOTOALLERGIC CONTACT DERMATITIS TO MUSK AMBRETTE: ACTION SPECTRA IN GUINEA PIGS AND MAN *
Author(s) -
Giovinazzo Vincent J.,
Ichikawa Hideyuki,
Kochevar Irene E.,
Armstrong Robert B.,
Harber Leonard C.
Publication year - 1981
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1981.tb05490.x
Subject(s) - erythema , dermatology , action spectrum , guinea pig , chemistry , medicine , photochemistry
Abstract— Positive photopatch tests to musk ambrette were elicited using narrow band radiation in two patients with photoallergic contact dermatitis to musk ambrette and in photosensitized guinea pigs. The most effective wavelength range in the two patients was between 334 and 394 nm. Control subjects did not respond to the same light doses either in the presence or absence of musk ambrette. One patient exhibited maximum sensitivity at 346 nm. The action spectrum in guinea pigs extended from 322 to 406 nm with maximum response at 322 nm. Below 322 nm, erythema was observed at the same or higher doses than those required for evoking a minimal erythema response in non‐sensitized animals. Morphologically and histologically the response below 322 nm appeared to be normal delayed erythema. No erythema was elicited by radiation between 322 and 430 nm in non‐photosensitized animals which had received musk ambrette.