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THE EFFECT OF pH ON THE FLUORESCENCE OF COMPLEXES OF HUMAN SERUM ALBUMIN AND BOVINE SERUM ALBUMIN WITH BILIRUBIN
Author(s) -
Lee J. J.,
Gillispie G. D.
Publication year - 1981
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1981.tb05486.x
Subject(s) - bovine serum albumin , bilirubin , chemistry , fluorescence , human serum albumin , albumin , serum albumin , serum bilirubin , biochemistry , chromatography , biology , endocrinology , physics , quantum mechanics
— Fluorescence studies as a function of pH clearly show that the environment and conformation of bilirubin bound to human serum albumin (HSA) are quite different than those for binding to bovine serum albumin (BSA). The visible fluorescence of the bilirubin‐BSA complex is maximal at the extremes of pH; in contrast, the bilirubin‐HSA complex fluorescence is at a maximum, near physiological pH.