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INHIBITION OF DNA REPAIR AND PRODUCTION OF SINGLE‐STRAND BREAKS IN ESCHERICHIA COLI BY REDUCTONE
Author(s) -
Leitão A. C.,
Caldas L. R.,
Gomes R. Alcantara
Publication year - 1981
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1981.tb04295.x
Subject(s) - escherichia coli , dna , chemistry , biochemistry , dna damage , dna repair , polymerase , escherichia , gene
— Reductone (HOCH 2 COCHO), a keto‐aldehyde produced by thermal degradation of some sugars, at alkaline pHs, blocks the excision repair of DNA lesions in uv‐irradiated wild type Escherichia coli. This probably occurs as a result of inhibition of the exonucleolytic activity of DNA polymerase I. In addition, reductone alone induces DNA single‐strand breaks. Repair of this damage is mainly dependent on the polA gene products.