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SPIN TRAPPING OF THE SUPEROXIDE RADICAL BY 4‐(N‐METHYLPYRIDINIUM) t ‐BUTYL NITRONE
Author(s) -
Sanderson Douglas G.,
Chedekel Miles R.
Publication year - 1980
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1980.tb04024.x
Subject(s) - nitrone , spin trapping , superoxide , chemistry , radical , adduct , aqueous solution , photochemistry , superoxide dismutase , superoxide radical , medicinal chemistry , organic chemistry , antioxidant , enzyme , catalysis , cycloaddition
— The synthesis of 4‐(N‐methylpyridinium) t‐butyl nitrone (4‐MePyBN) and its use as a spin trap for superoxide radicals produced in aqueous solutions is reported (a N = 13.78 G, a H ß = 1.65 G, and g = 2.0091). The half‐life of the spin adduct as a function of pH (83 s at pH 5.5, 78 s at pH 7.0, and 65 s at pH 8.0) the effects of iron salts, diethylenetriaminepentacetic acid (DETAPAC), and superoxide dismutase were examined, and comparisons made between 4‐MePyBN and 5,5‐dimethyl‐1‐pyrroline‐N‐oxide (DMPO) as spin trapping agents for the superoxide radical.