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NMR ANALYSES OF TRYPTOPHAN‐8‐METHOXYPSORALEN PHOTOREACTION PRODUCTS FORMED IN THE PRESENCE OF OXYGEN
Author(s) -
Megaw J.,
Lee‡ J.,
Lerman S.
Publication year - 1980
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1980.tb04019.x
Subject(s) - tryptophan , indole test , chemistry , moiety , photochemistry , reprint , oxygen , irradiation , imidazole , stereochemistry , organic chemistry , biochemistry , amino acid , physics , astronomy , nuclear physics
— Proton‐made spectroscopy was performed on solutions of l ‐tryptophan and 8‐mcthoxypsoralen (8‐MOP) in either D 2 O or DMSO‐d 6 in the presence of oxygen before and after irradiation with 360 nm monochromatic light. Irradiation results in the loss of hydrogen atoms at the 3. 4 and 4′. 5′ positions of 8‐MOP and at the indole C 2 position of tryptophan. Changes in the aliphatic regions of the spectra also occur with irradiation. It is postulated that generation of photoreaction products between 8‐MOP and tryptophan involves the 3.4 and 4′.5′ positions of 8‐MOP and the imidazole moiety of tryptophan. Reprint requests to: Dr J. Megaw, Laboratory for Ophthalmic Research, Emory University School of Medicine, Atlanta. Georgia 30322. USA.