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THE ROLE OF PYRIMIDINE DIMERS AND NON‐DIMER DAMAGE IN THE INACTIVATION OF ESCHERICHIA COLI BY UV RADIATION
Author(s) -
Hodges N. D. M.,
Moss S. H.,
Davies D. J. G.
Publication year - 1980
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1980.tb03748.x
Subject(s) - pyrimidine dimer , photolyase , escherichia coli , dimer , strain (injury) , chemistry , radiation damage , photochemistry , radiation , pyrimidine , irradiation , in vivo , biophysics , biology , dna damage , biochemistry , dna repair , dna , genetics , physics , optics , gene , anatomy , organic chemistry , nuclear physics
— We have quantitated the role of pyrimidine dimers and non‐dimer damage in the inactivation of Escherichia coli by far‐UV radiation, near‐UV radiation, and triplet state sensitized near‐UV radiation. The extent of photoreactivation in vivo of an excision and postreplication repair‐deficient strain of E. coli after the different radiation treatments has been correlated with the relative proportion of pyrimidine dimers and non‐dimer lesions produced. Using an excision deficient strain of E. coli, the susceptibility to recA + ‐dependent repair of the damage produced by the different radiation treatments has also been quantified.