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SENSITIVITY TO PHOTOADDITION OF MONO‐AND BIFUNCTIONAL FUROCOUMARINS OF X‐RAY SENSITIVE MUTANTS OF SACCHAROMYCES CEREVISIAE
Author(s) -
Henriques J. A. P.,
Moustacchi E.
Publication year - 1980
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1980.tb03746.x
Subject(s) - furocoumarins , saccharomyces cerevisiae , mutant , bifunctional , chemistry , furocoumarin , biology , microbiology and biotechnology , biochemistry , yeast , dna , photochemistry , gene , catalysis
— With the exception of rad53 , seven other X‐ray sensitive mutants of the rad50 serie of Saccharomyces cerevisiae were found to be more sensitive than the wild type to photoaddition of Afunctional (3‐methoxypsoralen) and monofunctional (3‐carbethoxypsoralen) furocoumarins. The magnitude of sensitivity to killing is dependent upon the locus and the phase of growth. This means that in addition to the two repair pathways (excision‐resynthesis and mutagenic pathways) previously shown to be involved in repair of furocoumarins photo‐induced lesions, a third pathway is implicated in the repair of such lesions.