Premium
CHLORPROMAZINE PHOTOSENSITIZATION–II. FAILURE TO DETECT ANY EVIDENCE FOR INVOLVEMENT OF DNA DAMAGE IN THE PHOTODYNAMIC KILLING OF ESCHERICHIA COLI IN THE PRESENCE OF CHLORPROMAZINE
Author(s) -
Matsuo Itsuro,
Ohkido Muneo,
Fujita Hitoshi,
Suzuki Kenshi
Publication year - 1980
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1980.tb03700.x
Subject(s) - lysogenic cycle , prophage , escherichia coli , reversion , auxotrophy , chlorpromazine , microbiology and biotechnology , dna damage , dna , cytotoxic t cell , chemistry , biology , arginine , gene , phenotype , bacteriophage , biochemistry , in vitro , pharmacology , amino acid
— When a suspension of Escherichia coli was irradiated with near‐UV light in the presence of chlorpromazine (at a concentration below a cytotoxic level), the cells were killed. Efficiency of the photodynamic killing was not influenced by the deficiency of the uvrA gene or the recA gene. Neither phenotypic reversion of E. coli Hs30R (arginine auxotroph) nor induction of lambda prophage in lysogenic bacteria was detected after this treatment.