Premium
CHLORPROMAZINE PHOTOSENSITIZATION—I. EFFECT OF NEAR‐UV IRRADIATION ON BACTERIOPHAGES SENSITIZED WITH CHLORPROMAZINE
Author(s) -
Matsuo Itsuro,
Ohkido Muneo,
Fijita Hitoshi,
Suzuki Kenshi
Publication year - 1980
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1980.tb03699.x
Subject(s) - chlorpromazine , bacteriophage , irradiation , chemistry , mutant , biophysics , adsorption , dna , pharmacology , biochemistry , biology , escherichia coli , physics , organic chemistry , nuclear physics , gene
— Both DNA bacteriophage and RNA bacteriophage were inactivated when they were irradiated with near‐UV light (black light) in the presence of chlorpromazine. The far‐UV sensitive mutants of T4D, i.e. T4D v , T4D px and T4D y , were no more sensitive to near‐UV light plus chlorpromazine than the wild type. Electron microscopic observations showed that adsorption of T4D was greatly influenced by the treatment. The present results may indicate that the inactivation of T4D is due to the loss of adsorption caused by impairment in the tail or the tail fiber protein rather than the inactivation of DNA.