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INHIBITION OF UV AND PSORALEN‐PLUS‐LIGHT MUTAGENESIS IN PHAGE T4 BY GENE 43 ANTIMUTATOR POLYMERASE ALLELES
Author(s) -
Yarosh, Daniel B.,
Johns Virginia,
Mufti Siraj,
Bernstein Carol,
Bernstein Harris
Publication year - 1980
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1980.tb02551.x
Subject(s) - reversion , psoralen , mutagenesis , allele , mutant , biology , polymerase , microbiology and biotechnology , nonsense mutation , dna polymerase , gene , dna , genetics , mutation , phenotype , missense mutation
— Mutagenesis by UV light or psoralen‐plus‐light was measured by increases in the reversion of nonsense mutants of phage T4. In the presence of either of two gene 43 antimutator polymerase alleles, ts CB120 or ts CB87, UV‐induced reversion was inhibited. Likewise psoralen‐plus‐light mutagenesis was inhibited when the ts CB120 allele was present. These results imply that the gene 43 DNA polymerase has a role in the formation of mutations from the DNA lesions induced by UV and psoralen‐plus‐light.