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FACTORS INFLUENCING THE NEAR‐UV EFFECT ON DNA IN THE PRESENCE OF 8‐METHOXYPSORALEN: RENATURABILITY OF DNA.
Author(s) -
Fujita Hitoshi,
Sano Miyaharu,
Suzuki Kenshi
Publication year - 1979
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1979.tb09263.x
Subject(s) - methoxsalen , dna , photochemistry , chemistry , ion , fluence , biophysics , biology , biochemistry , organic chemistry , psoriasis , immunology
— Factors affecting the near‐UV induced reaction of calf thymus DNA in the presence of 8‐methoxypsoralen were examined. DNA became more renaturable with increasing concentration of 8‐methoxypsoralen and fluence. Existence of paramagnetic ions, Mn 2+ , Co 2+ , or Ni 2 + , largely repressed the photoreaction. It was ascertained that the highest renaturability was attained by the illumination with light between 310 and 345 nm.