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A SEROLOGICAL STUDY OF REMOVAL OF UV‐INDUCED PHOTOPRODUCTS IN THE DNA OF TETRANYMEN A PYRIFORMIS GL: INFLUENCE OF CAFFEINE, QUINACRINE AND CHLOROQUINE
Author(s) -
Lakhanisky Th.,
Hedrickx B.,
Mouton R. F.,
Cornelis J. J.
Publication year - 1979
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1979.tb07778.x
Subject(s) - tetrahymena pyriformis , chloroquine , caffeine , dna , antiserum , chemistry , serology , microbiology and biotechnology , biology , antibody , biochemistry , tetrahymena , genetics , immunology , malaria , endocrinology
—Antisera that recognize specifically UV‐photoproducts in DNA have been used to follow the elimination of photolesions in UV irradiated Tetrahymena pyriformis . The amount of bound tritiumlabelled antibodies to nuclei has been estimated by autoradiography. Curves of dose‐response of DNA photoproducts, their elimination by dark repair, and effect of caffeine, quinacrine and chloroquine on the disappearance of UV‐lesions have been evaluated.