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CHLORPROMAZINE AND PROTRIPTYLINE PHOTOTOXICITY: PHOTOSENSITIZED, OXYGEN INDEPENDENT RED CELL HEMOLYSIS
Author(s) -
Kochevar Irene E.,
LAmola Angelo A.
Publication year - 1979
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1979.tb07768.x
Subject(s) - phototoxicity , chlorpromazine , lysis , hemolysis , chemistry , red cell , oxygen , red blood cell , pharmacology , biophysics , biochemistry , medicine , immunology , biology , organic chemistry , in vitro
—Red blood cell lysis photosensitized by chlorpromazine and protriptyline was investigated. Oxygen independent sensitized photohemolysis was observed with both compounds. When chlorpromazine and protriptyline were irradiated in the absence of red cells, both formed photoproducts which lysed red cells. These results indicate that chlorpromazine and protriptyline represent a new mechanistic class of phototoxic compounds which photosensitize membrane disruption by oxygen independent processes.