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FORMATION OF SINGLET MOLECULAR OXYGEN BY 8‐METHOXYPSORALEN *
Author(s) -
Mol N. J. de,
Henegouwen G. M. J. Beijersbergen
Publication year - 1979
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1979.tb07364.x
Subject(s) - singlet oxygen , chemistry , photochemistry , methylene blue , acceptor , singlet state , oxygen , molecular oxygen , methylene , excited state , molecule , medicinal chemistry , catalysis , organic chemistry , photocatalysis , physics , nuclear physics , condensed matter physics
— The formation of singlet molecular oxygen ( l O 2 ) by energy transfer from the excited 8‐meth‐oxypsoralen (8‐MOP) molecule was investigated. This was done in several ways: (a) In the reaction of irradiated 8‐MOP with the 1 O 2 acceptor 2‐methyl‐2‐pentene, the characteristic oxidation products were identified. (b) The rate of the 8‐MOP sensitized photooxidation of 3, 4‐dihydroxy phenylalanine (dopa), which appeared to be also a useful 1 O 2 acceptor, was larger in D 2 O than in H 2 O. (c) The β‐values for reaction of 1 O 2 with dopa in the presence of 8‐MOP or of methylene blue as 1 O 2 generators were in accordance with each other. The consequences of 1 O 2 formation by 8‐MOP sensitization is discussed for the clinical use of this compound.