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THE WAVELENGTH DEPENDENCE OF 8‐METHOXYPSORALEN PHOTOSENSITIZATION OF HOST CAPACITY INACTIVATION IN A MAMMALIAN CELL‐VIRUS SYSTEM
Author(s) -
Coohill Thomas P.,
James Leslie C.
Publication year - 1979
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1979.tb07141.x
Subject(s) - action spectrum , virus , chemistry , absorption (acoustics) , biophysics , herpes simplex virus , host (biology) , cell culture , photochemistry , biology , virology , genetics , physics , optics
— The addition of 8‐methoxypsoralen to cultures of African green monkey cells (CV‐I) sensitized the inactivation by near UV radiation (302–370 nm) of the ability of the cells to host herpes simplex virus. No sensitizing effect by drug addition was noted for far UV radiation (232–297 nm). An action spectrum for the photosensitized inactivation of this cellular parameter was obtained. This action spectrum is consistent with the absorption spectrum of 8‐methoxypsoralen.