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CHANGES IN SUPEROXIDE DISMUTASE, CATALASE AND GLUCOSE‐6‐PHOSPHATE DEHYDROGENASE ACTIVITIES OF RABBIT ALVEOLAR MACROPHAGES: INDUCED BY POSTNATAL MATURATION AND/OR IN VITRO HYPEROXIA
Author(s) -
Nerurkar Lata S.,
Zeligs Barbara J.,
Bellanti Joseph A.
Publication year - 1978
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1978.tb07019.x
Subject(s) - superoxide dismutase , catalase , hyperoxia , chemistry , superoxide , biochemistry , dehydrogenase , glucose 6 phosphate dehydrogenase , microbiology and biotechnology , biology , enzyme , andrology , oxygen , medicine , organic chemistry
— The total superoxide dismutase activity of rabbit alveolar macrophages (AM) increased twofold during the first postnatal week. This increase in superoxide dismutase activity was primarily mitochondrial and paralleled the increase in the number of mitochondria in these cells which has been previously reported. The superoxide dismutase activity of AM in culture for 18 h was significantly increased by hyperoxia; catalase activity in hyperoxic conditions was slightly adversely affected; glucose‐6‐phosphate dehydrogenase activity was increased but not significantly over control values. Hyperoxic cultures beyond 42 h decreased the total number of viable cells and the superoxide dismutase activity expressed per viable cell; the disappearance of catalase and glucose‐6‐phosphate dehydrogenase activities in this period, however, was more rapid in control alveolar macrophages than those under hyperoxia.