Premium
THE SENSITISING EFFECT OF A SUNSCREENING AGENT, p ‐AMINOBENZOIC ACID, ON NEAR UV INDUCED DAMAGE IN A REPAIR DEFICIENT STRAIN OF ESCHERICHIA COLI *
Author(s) -
Hodges N. D. M.,
Moss S. H.,
Davies D. J. G.
Publication year - 1977
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1977.tb07520.x
Subject(s) - escherichia coli , strain (injury) , pyrimidine dimer , ultraviolet , bacteria , dna repair , dna damage , chemistry , dna , biology , microbiology and biotechnology , biochemistry , genetics , materials science , gene , optoelectronics , anatomy
. The use of repair deficient strains of bacteria for detecting mutagenic properties of chemical species is now an established technique. In this paper we present inactivation results obtained with Escherichia coli K12 AB2480 ( uvr A rec A ) which indicate that p ‐aminobenzoic acid, a common component of sunscreening formulations, may increase the frequency of lethal damage induced in DNA when cell populations are exposed to near ultraviolet radiation. Preliminary experiments, utilising the selective action of photoenzymatic repair, indicated that the sensitisation to near ultraviolet radiation is partially but not wholly due to increased formation of pyrimidine dimers.