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THE PHOTODYNAMIC IMMOBILIZATION OF ARTEMIA SALINA NAUPLII BY POLYCYCLIC AROMATIC HYDROCARBONS AND ITS RELATIONSHIP TO CARCINOGENIC ACTIVITY
Author(s) -
Morgan David D.,
Warshawsky David
Publication year - 1977
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1977.tb07422.x
Subject(s) - artemia salina , carcinogen , chemistry , acridine , photodynamic therapy , irradiation , acridine derivatives , environmental chemistry , biochemistry , toxicity , stereochemistry , organic chemistry , physics , nuclear physics
— The rates of the photosensitized immobilization of the nauplii of the crustacean Artemia salina were measured as a function of irradiation time and the amount of light absorbed by the sensitizers. The nauplii were incubated in the dark in dilute solutions of the sensitizers for periods of 2 and 22 h prior to irradiation. Nineteen carcinogenic and 22 noncarcinogenic polycyclic aromatic hydrocarbons were used as sensitizers. Relative photodynamic activities (RPA) were determined from the rates of immobilization using benz[ c ]acridine as a standard (RPA = 1). High RPA was restricted to carcinogenic compounds with 4 and 5 fused rings, compounds with 6 or more fused rings had low RPA regardless of their carcinogenic activities. The correlation of RPA with carcinogenic activity was excellent ( P = 0.006 and 0.009 for the 2 and 22 h dark incubations, respectively). It is suggested that carcinogenesis by polycyclic aromatics may result from sublethal photodynamic effects.