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INHERITANCE OF PHOTOREACTIVATING ENZYME DEFICIENCIES IN HUMAN CELLS
Author(s) -
Sutherland Betsy M.,
Oliver Rowena
Publication year - 1976
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1976.tb06853.x
Subject(s) - xeroderma pigmentosum , enzyme , biology , genetics , inheritance (genetic algorithm) , enzyme assay , dna , biochemistry , dna repair , gene
— Cells from patients with xeroderma pigmentosum contain lowered levels of photoreactivating enzyme. We have examined the photoreactivating enzyme levels in cells from members of a family with three xeroderma children, one normal child and normal parents; the enzyme levels are consistent with a simple pattern of inheritance in which individuals with the normal enzyme level are PP , those with intermediate levels are PP , and those with very low enzyme levels are pp. We tested this hypothesis by examining enzyme levels in parent‐xeroderma child pairs in which the child possessed very low enzyme levels ( pp ). In all cases, the parents contained intermediate levels of enzyme ( Pp ). These results support the hypothesis of a simple pattern of inheritance of photoreactivating enzyme in humans.