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EFFECT OF SINGLET OXYGEN QUENCHERS ON OXIDATIVE DAMAGE TO LIPOSOMES INITIATED BY PHOTOSENSITIZATION OR BY RADIOFREQUENCY DISCHARGE
Author(s) -
Anderson S. M.,
Krinsky N. I.,
Stone M. J.,
Clagett D. C.
Publication year - 1974
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1974.tb06549.x
Subject(s) - singlet oxygen , liposome , dabco , chemistry , photochemistry , malondialdehyde , porphyrin , oxidative phosphorylation , oxygen , lysis , membrane , biophysics , organic chemistry , biochemistry , octane , oxidative stress , biology
—Lipid model membrane systems, liposomes, may be oxidized by both toluidine blue Osensitized photo‐oxidation and radiofrequency‐discharge‐generated singiet oxygen. Oxidation can be followed by the appearance of lipid peroxides, malondialdehyde formation, and ultimately by the lysis of the liposomes. Inhibition of oxidation is observed in both systems using either β‐carotene or DABCO. These observations are consistent with the view that type II (singlet oxygen) reactions are involved in this photodynamic system.