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THE FORMATION OF PHOTOREVERSIBLE CYCLOBUTANE‐TYPE PYRIMIDINE DIMERS IN ULTRAVIOLET‐IRRADIATED POTATO VIRUS X *
Author(s) -
Huang C. W.,
Gordon Milton P.
Publication year - 1974
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1974.tb06510.x
Subject(s) - pyrimidine dimer , cyclobutane , infectivity , virus , ultraviolet , chemistry , pyrimidine , photochemistry , ultraviolet irradiation , irradiation , ultraviolet light , dimer , dna , biology , stereochemistry , virology , biochemistry , dna damage , ring (chemistry) , materials science , organic chemistry , physics , optoelectronics , nuclear physics
— Photoreversible cyclobutane‐type pyrimidine dimers were found in 32 P‐labeled RN A isolated from intact potato virus X irradiated with 254 nm light. The number of dimers was correlated with the biological infectivity of the ultraviolet‐treated virus. Assuming that incorporated 32 P is homogeneously distributed in the viral RNA chain, it can be calculated that about 5·7±1·7 dimers are present in each strand of virus per lethal biological hit.