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THEORETICAL ASPECTS OF THE U.V. INACTIVATION OF PROTEINS CONTAINING DISULFIDE BONDS
Author(s) -
Dose Klaus
Publication year - 1967
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1967.tb08890.x
Subject(s) - cystine , excited state , chemistry , disulfide bond , amino acid , enzyme , quantum chemical , stereochemistry , biochemistry , organic chemistry , molecule , cysteine , physics , quantum mechanics
Equations are proposed for the estimation of quantum yields for cystine destruction and disulfide protein inactivation during u.v.‐irradiation in acidic and neutral solutions. The formulas permit a discussion of energy transfer from excited aromatic amino acids to cystines and/or of chemical reactions between excited tryptophans or tyrosines and cystines. The results are discussed with regard to general aspects of the photo‐biochemistry of enzymes.