Premium
ZUM WIRKUNGSMECHANISMUS PHOTODYNAMISCHER FUROCUMARINE PHOTOREAKTION VON PSORALEN‐(4‐ 14 C) MIT DNS, RNS, HOMOPOLYNUCLEOTIDEN UND NUCLEOSIDEN
Author(s) -
Krauch C. H.,
Krämer D. M.,
Wacker A.
Publication year - 1967
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1967.tb08882.x
Subject(s) - psoralen , uracil , thymine , chemistry , uridine , stereochemistry , dna , double bond , rna , biochemistry , organic chemistry , gene
— The photodynamic binding of psoralen to DNA and RNA was shown using different methods. This binding was found to be mainly located either at thymine or uracil. The concentration and pH dependancy was studied. The photoproduct obtained with uridine was isolated paper chromatographically and was split into initial components photochemically. The results bring an evidence that psoralen with its 3,4‐double bond is able to form a cyclic derivative with the C 6 ‐C 6 doble bond of thymine or uracil.