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EFFECTS OF ULTRAVIOLET RADIATION ON ANTIGENICITY OF HORSE SERUM ALBUMIN: FORMATION OF NEW DETERMINANTS
Author(s) -
Kleczkowski A.,
Gold A. H.
Publication year - 1962
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1962.tb08105.x
Subject(s) - antigenicity , antiserum , albumin , horse , bovine serum albumin , ultraviolet radiation , ultraviolet irradiation , serum albumin , chemistry , ultraviolet , antibody , irradiation , biochemistry , biology , immunology , optics , physics , paleontology , nuclear physics , radiochemistry
Summary Structural alterations in horse serum albumin caused by ultraviolet radiation resulted in disappearance of the original determinants and in formation of new determinants. There was, however, enough similarity between the original and the new determinants for antibodies produced by the new determinants to show a weak affinity to the non‐irradiated albumin. Only weak antisera were produced by injecting rabbits with extensively irradiated albumin.