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THE PHOTODYNAMIC EFFECTS OF ACRIDINE ORANGE ON AN RNA VIRUS (VESICULAR EXANTHEMA)*
Author(s) -
Hackett A. J.
Publication year - 1962
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1962.tb08087.x
Subject(s) - acridine orange , virus , biology , acridine , virology , chemistry , rna , biophysics , biochemistry , genetics , apoptosis , gene
Summary Free vesicular exanthema of swine virus (VESV) suspended in an acridine orange (AO) solution is not light sensitive. The simultaneous introduction to the host of AO and VESV results in progeny that are sensitive to light. The introduction of AO during the eclipse period of viral growth results in progeny sensitive to light. Introduction of AO during the exponential rise in the production of mature virus, however, results in some light sensitive particles among a majority of insensitive particles. The data presented show that the lethal effect of AO is produced only after light exposure, indicating that the mutagenic action of the dye may not be due to its presence per se .