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Duration of serological response to canine parvovirus‐type 2, canine distemper virus, canine adenovirus type 1 and canine parainfluenza virus in client‐owned dogs in A ustralia
Author(s) -
Mitchell SA,
Zwijnenberg RJ,
Huang J,
Hodge A,
Day MJ
Publication year - 2012
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.2012.01009.x
Subject(s) - canine distemper , canine parvovirus , serology , virology , parvovirus , virus , titer , vaccination , medicine , antibody , biology , immunology
Objective To determine whether client‐owned dogs in Australia, last vaccinated with C anvac® vaccines containing canine parvovirus‐type 2 ( CPV ‐2), canine distemper virus ( CDV ), canine adenovirus type 2 ( CAV ‐2) ± canine parainfluenza virus ( CPiV ) at least 18 months ago, were seropositive or responded serologically to revaccination. Methods A total of 235 dogs were recruited from 23 veterinary clinics, representing a variety of breeds, ages and time since last vaccination ( TSLV : range 1.5–9 years, mean 2.8 years). Dogs had a blood sample taken and were revaccinated on day 0. A second blood sample was taken 7–14 days later. Blood samples were assessed for antibody titres to CPV ‐2 (by haemagglutination inhibition) and CDV , CAV type 1 ( CAV ‐1) and CPiV (by virus neutralisation). Dogs with a day 0 titre >10 or a four‐fold increase in titre following revaccination were considered to be serological responders. Results The overall percentage of dogs classified as serological responders was 98.7% for CPV ‐2, 96.6% for CDV , 99.6% for CAV ‐1 and 90.3% for CPiV . Conclusions These results suggest that the duration of serological response induced by modified‐live vaccines against CPV ‐2, CDV , CAV ‐1 and CPiV , including C anvac® vaccines, is beyond 18 months and may extend up to 9 years. Accordingly, these vaccines may be considered for use in extended revaccination interval protocols as recommended by current canine vaccine guidelines.