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Congenital dyserythropoietic anaemia and dyskeratosis in Australian Poll Hereford calves
Author(s) -
Kessell AE,
Hanshaw DM,
Finnie JW,
Nosworthy P
Publication year - 2012
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.2012.00998.x
Subject(s) - dyskeratosis congenita , hyperkeratosis , dyskeratosis , pathological , pathology , haematopoiesis , bone marrow , biology , keratosis , medicine , genetics , stem cell , telomerase , gene
Congenital dyserythropoietic anaemia ( CDA ) is a heterogeneous group of rare genetic disorders that in humans is characterised by ineffective haematopoiesis with morphological abnormalities in erythroid precursor cells and secondary iron overload. In the 1990s, a syndrome of CDA with dyskeratosis and progressive alopecia was reported in P oll H ereford calves in C anada and the USA . We report the clinical and pathological findings in two P oll H ereford calves with this syndrome from separate properties in S outh A ustralia. The animals had a variably severe anaemia, associated with abnormal nucleated red blood cells in peripheral blood, and large numbers of rubricytes and metarubricytes with a characteristic nuclear ultrastructure in the bone marrow. Both calves were born with a wiry hair coat and a progressively ‘dirty‐faced’ appearance associated with hyperkeratosis and dyskeratosis (apoptosis).