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Hypokalaemic paresis, hypertension, alkalosis and adrenal‐dependent hyperadrenocorticism in a dog
Author(s) -
Davies DR,
Foster SF,
Hopper BJ,
Staudte KL,
O’hara AJ,
Irwin PJ
Publication year - 2008
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.2008.00276.x
Subject(s) - medicine , metabolic alkalosis , kaliuresis , endocrinology , aldosterone , hyperaldosteronism , hypokalemia , paresis , adrenocortical carcinoma , alkalosis , mineralocorticoid , blood pressure , surgery , natriuresis , acidosis
Generalised paresis, severe hypokalaemia and kaliuresis, metabolic alkalosis and hypertension, characteristic of mineralocorticoid excess, were identified in a dog with hyperadrenocorticism due to a functional adrenocortical carcinoma. Aldosterone concentration was decreased and deoxycorticosterone concentration increased in the presence of hypokalaemia. These metabolic abnormalities resolved with resection of the carcinoma. Mineralocorticoid excess in dogs with hyperadrenocorticism is generally considered to be of little clinical significance but resulted in the acute presentation of this patient. The possible pathogenesis of mineralocorticoid excess in this case of canine hyperadrenocorticism is discussed.